Dichloromethane → 1-[(4-Hydroxy-pyrrolidine-2-carbonyl)-amino]-2-vinyl-cyclopropanecarboxylic acid ethyl ester

HRID 2162776Notes

Reaction equation

HRID 2162776 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH:9]([C:14]([NH:15][C:16]2([C:21](=[O:22])[O:23][CH2:24][CH3:25])[CH:17]([CH:19]=[CH2:20])[CH2:18]2)=[O:26])[CH2:10][CH:11]([OH:13])[CH2:12]1)([CH3:5])([CH3:6])[CH3:7].[Cl:34][CH2:35][Cl:36].[F:27][C:28]([F:29])([F:30])[C:31]([OH:32])=[O:33]>>[NH:8]1[CH:9]([C:14]([NH:15][C:16]2([C:21](=[O:22])[O:23][CH2:24][CH3:25])[CH:17]([CH:19]=[CH2:20])[CH2:18]2)=[O:26])[CH2:10][CH:11]([OH:13])[CH2:12]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 235716032-(1-Ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 668712681-[(4-Hydroxy-pyrrolidine-2-carbonyl)-amino]-2-vinyl-cyclopropanecarboxylic acid ethyl ester

Sources & evidence

ORD record
ord-16403cb9ca8f472a89134bfca1e773fa
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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