反应详情

A solution of the product of Example 143C (5.4 g) in tetrahydrofuran (80 mL) was treated with carbonydiimidazole (6.1 g, 2 equivalents) at 25° C. for 2 hrs. The mixture was quenched with 10% citric acid, the organic layer was separated, washed with water, brine, dried over Na2SO4, filtered, and the solvents were evaporated A solution of the residue (3.3 g) in dioxane (20 mL) was treated with 1M LiOH (20 mL) at 25° C. for 2 hrs. The solvents were evaporated, and the residue was acidified with 10% HCl, extracted with dichloromethane/2-propanol (3:1), the organic layer was separated, dried over Na2SO4, filtered, and the solvents evaporated to give 1.5 g of the title compound.

1. customThe mixture was quenched with 10% citric acid
2. customthe organic layer was separated
3. washwashed with water, brine
4. dry with materialdried over Na2SO4
5. filtrationfiltered
6. customthe solvents were evaporated A solution of the residue (3.3 g) in dioxane (20 mL)
7. additionwas treated with 1M LiOH (20 mL) at 25° C. for 2 hrs
8. customThe solvents were evaporated
9. extractionextracted with dichloromethane/2-propanol (3:1)
10. customthe organic layer was separated
11. dry with materialdried over Na2SO4
12. filtrationfiltered
13. customthe solvents evaporated