Diethyl Ether → 5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-(1-hydroxybutan-2-yl)-3-prop-2-enylpiperidin-2-one

HRID 2162980Notes

Reaction equation

HRID 2162980 reaction equation
[BH4-:32].[CH2:1]([CH:2]=[CH2:3])[CH:4]1[C:5](=[O:31])[N:6]([CH:24]([C:25](=[O:26])[O:27][CH3:28])[CH2:29][CH3:30])[CH:7]([c:17]2[cH:18][cH:19][c:20]([Cl:23])[cH:21][cH:22]2)[CH:8]([c:10]2[cH:11][c:12]([Cl:16])[cH:13][cH:14][cH:15]2)[CH2:9]1.[CH3:34][CH2:35][O:36][CH2:37][CH3:38].[Li+:33]>>[CH2:1]([CH:2]=[CH2:3])[CH:4]1[C:5](=[O:31])[N:6]([CH:24]([CH2:25][OH:26])[CH2:29][CH3:30])[CH:7]([c:17]2[cH:18][cH:19][c:20]([Cl:23])[cH:21][cH:22]2)[CH:8]([c:10]2[cH:11][c:12]([Cl:16])[cH:13][cH:14][cH:15]2)[CH2:9]1

Participants

5

Reactant 4

HCID 3283Diethyl EtherHCID 28123BorohydrideHCID 28486Lithium ionHCID 76834658Methyl 2-[3-(3-chlorophenyl)-2-(4-chlorophenyl)-6-oxo-5-prop-2-enylpiperidin-1-yl]butanoate

Product 1

HCID 768347065-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-(1-hydroxybutan-2-yl)-3-prop-2-enylpiperidin-2-one

Sources & evidence

ORD record
ord-ce8bf72e75aa46eaacc7153fe2eb9e12
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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