HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → N-Methyl-1-(2-methyl-1,3-thiazol-4-yl)methanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | 4-(Chloromethyl)-2-methyl-1,3-thiazole | HCID 736341 | — |
| Product | N-Methyl-1-(2-methyl-1,3-thiazol-4-yl)methanamine | HCID 18939489 | 99% |
Reaction Steps
2-Methyl-4-(chloromethyl)thiazole (2.94 g, CAS#39238-07-8) was dissolved in 40% methylamine (39 mL, 25 equivalents) at 25° C. for 1 h. The mixture was evaporated and purified using 10% methanol/dichloromethane with 0.5% NH4OH to give 2.83 g (99%) of the amine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08193227B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-c0e846b89e964b2d8171051bae56c30c |
| Source note | uspto-grants-2012_06 |