Methylamine → N-Methyl-1-(2-methyl-1,3-thiazol-4-yl)methanamine

HRID 216300Notes

Reaction equation

HRID 216300 reaction equation
[CH3:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7]Cl)[N:6]=1.[CH3:9][NH2:10]>>[CH3:9][NH:10][CH2:7][C:5]1[N:6]=[C:2]([CH3:1])[S:3][CH:4]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 7363414-(Chloromethyl)-2-methyl-1,3-thiazole

Product 1

HCID 18939489N-Methyl-1-(2-methyl-1,3-thiazol-4-yl)methanamineYield 99%

Procedure

2-Methyl-4-(chloromethyl)thiazole (2.94 g, CAS#39238-07-8) was dissolved in 40% methylamine (39 mL, 25 equivalents) at 25° C. for 1 h. The mixture was evaporated and purified using 10% methanol/dichloromethane with 0.5% NH4OH to give 2.83 g (99%) of the amine.

Workup

  1. customThe mixture was evaporated
  2. custompurified

Sources & evidence

ORD record
ord-c0e846b89e964b2d8171051bae56c30c
Source dataset
uspto-grants-2012_06
Patent number
US08193227B2

Reaction notes

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