Dichloromethane → HCID 55279814, compound

HRID 216305Notes

Reaction equation

HRID 216305 reaction equation
[Cl:1][S:2]([OH:5])(=O)=[O:3].[Cl:6][C:7]1[CH:12]=[CH:11][C:10](C)=[CH:9][C:8]=1[OH:14].Cl[CH2:16]Cl>>[Cl:6][C:7]1[CH:12]=[C:11]([S:2]([Cl:1])(=[O:5])=[O:3])[CH:10]=[C:9]([CH3:16])[C:8]=1[OH:14]

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 120082-Chloro-5-methylphenolHCID 24638Chlorosulfonic acid

Product 1

HCID 55279814HCID 55279814, compoundYield 11.3%

Procedure

To a solution of chlorosulfonic acid (1.22 g, 10.5 mmol) dissolved in 10 mL of dichloromethane was added 2-chloro-5-methylphenol (1.0 g, 7.0 mmol) dropwise. After 10 minutes, the reaction was quenched by pouring it into ice water. The reaction was extracted with dichloromethane, washed with brine, dried over MgSO4, filtered, and concentrated to give 190 mg (11.3%) of the title compound.

Workup

  1. customthe reaction was quenched
  2. additionby pouring it into ice water
  3. extractionThe reaction was extracted with dichloromethane
  4. washwashed with brine
  5. dry with materialdried over MgSO4
  6. filtrationfiltered
  7. concentrationconcentrated

Sources & evidence

ORD record
ord-f4765f989a31423ca11b2b71783b7dde
Source dataset
uspto-grants-2012_06
Patent number
US08193227B2

Reaction notes

Loading…