Ethanol → HCID 86736242, compound

HRID 2163156Notes

Reaction equation

HRID 2163156 reaction equation
[F:1][C:2]([F:14])([F:13])[C:3]1[CH:11]=[C:10]2[C:6]([CH2:7][CH2:8][C:9]2=O)=[CH:5][CH:4]=1.Cl.[NH2:16][OH:17].N1C=CC=CC=1.C(O)C>O>[F:1][C:2]([F:14])([F:13])[C:3]1[CH:11]=[C:10]2[C:6]([CH2:7][CH2:8][C:9]2=[N:16][OH:17])=[CH:5][CH:4]=1

Participants

6

Reactant 4

HCID 702EthanolHCID 1049PyridineHCID 443297Hydroxyamine hydrochlorideHCID 227541286-(Trifluoromethyl)-1-indanone

Product 1

HCID 86736242HCID 86736242, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

One gram of 6-trifluoromethyl-1-indanone was converted to the corresponding oxime by reaction with 1.92 g. of hydroxylamine hydrochloride in 4 ml. of pyridine and 20 ml. of anhydrous ethanol. The mixture was refluxed for 24 hours and then poured into cold water. The oxime precipitated and was separated by filtration. The filter cake was washed with hot water. 1.02 g. of a white powdery solid melting at 128°-32° C. comprising 6-trifluoromethyl-1-indanone oxime were obtained. The compound melted at 132°-7° C. after recrystallization from an ethyl acetatecyclohexane solvent mixture.

Workup

  1. temperatureThe mixture was refluxed for 24 hours
  2. customThe oxime precipitated
  3. customwas separated by filtration
  4. washThe filter cake was washed with hot water

Sources & evidence

ORD record
ord-c778310cc195494e89556477129a6081
Source dataset
uspto-grants-1979_01
Patent number
US04132737

Reaction notes

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