反应详情

One gram of 6-trifluoromethyl-1-indanone was converted to the corresponding oxime by reaction with 1.92 g. of hydroxylamine hydrochloride in 4 ml. of pyridine and 20 ml. of anhydrous ethanol. The mixture was refluxed for 24 hours and then poured into cold water. The oxime precipitated and was separated by filtration. The filter cake was washed with hot water. 1.02 g. of a white powdery solid melting at 128°-32° C. comprising 6-trifluoromethyl-1-indanone oxime were obtained. The compound melted at 132°-7° C. after recrystallization from an ethyl acetatecyclohexane solvent mixture.

1. temperatureThe mixture was refluxed for 24 hours
2. customThe oxime precipitated
3. customwas separated by filtration
4. washThe filter cake was washed with hot water