Hydrochloric Acid → HCID 178509091, compound

HRID 2163215Notes

Reaction equation

HRID 2163215 reaction equation
[NH:1]=[C:2]1[NH:6][C:5]([CH:7]([S:13]([OH:16])(=[O:15])=[O:14])[C:8]([O:10]CC)=[O:9])=[CH:4][S:3]1.[OH-].[Na+].Cl>>[S:13]([CH:7]([C:5]1[NH:6][C:2](=[NH:1])[S:3][CH:4]=1)[C:8]([OH:10])=[O:9])([OH:16])(=[O:14])=[O:15]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 178470765HCID 178470765, compound

Product 1

HCID 178509091HCID 178509091, compoundYield 86.8%

Procedure

Under cooling with ice and stirring, 798 mg of the above ethyl (2-imino-4-thiazolin-4-yl)-2-sulfoacetate is added to 6.6 ml of 1N-sodium hydroxide and the mixture is allowed to stand for 15 minutes. Then, under cooling with ice and stirring, the mixture is neutralized with 7.0 ml of 1N hydrochloric acid, whereupon white precipitate is obtained. The precipitate is recovered by filtration, rinsed with ethanol and ether and dried. By this procedure is obtained 620 mg of 2-sulfo-2-(2-imino-4-thiazolin-4-yl)acetic acid. IR(cm-1, KBr): 1732, 1628, 1603, 1576, 1230, 1190, 1050 NMR(NaHCO3 in D2Q, δ): 4.93(s,1H), 6.90(s,1H)

Workup

  1. temperatureUnder cooling with ice
  2. temperatureThen, under cooling with ice
  3. stirringstirring
  4. customis obtained
  5. filtrationThe precipitate is recovered by filtration
  6. washrinsed with ethanol and ether
  7. customdried

Sources & evidence

ORD record
ord-3686a19dfe8c4ac88a50a338d675cfaa
Source dataset
uspto-grants-1979_01
Patent number
US04132789

Reaction notes

Loading…