HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → 10-(5-Methyl-1-pyrrolin-2-YL)-2-(trifluoromethyl)phenoxazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 5-Methyl-2-pyrrolidone | HCID 66055 | — |
| Reactant | 2-Trifluoromethylphenoxazine | HCID 10467321 | — |
| Product | 10-(5-Methyl-1-pyrrolin-2-YL)-2-(trifluoromethyl)phenoxazine | HCID 22754258 | — |
Reaction Steps
Reaction of 2-(trifluoromethyl)phenoxazine, 5-methyl-2-pyrrolidinone and phosphorous oxychloride according to the procedure of Example 1 provides the free base 10-(5-METHYL-1-PYRROLIN-2-YL)-2-(TRIFLUOROMETHYL)PHENOXAZINE as a distillable oil, b.p. 145-152° C. at 0.03 mm Hg. Conversion of the free base to the hydrochloride salt affords 10-(5-METHYL-1-PYRROLIN-2-YL)-2-(TRIFLUOROMETHYL)PHENOXAZINE HYDROCHLORIDE, m.p. 192.5-195.5° C. (dec.) (corr.), in a 45% overall yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04132794 |
| Source dataset | uspto-grants-1979_01 |
| ORD ID | ord-2625e70668e54951a28c57e8ebc406d9 |
| Source note | uspto-grants-1979_01 |