Phosphorus oxychloride → 10-(5-Methyl-1-pyrrolin-2-YL)-2-(trifluoromethyl)phenoxazine

HRID 2163236노트

반응식

HRID 2163236 반응식
[F:1][C:2]([F:18])([F:17])[C:3]1[CH:16]=[CH:15][C:14]2[O:13][C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[NH:6][C:5]=2[CH:4]=1.[CH3:19][CH:20]1[NH:24][C:23](=O)[CH2:22][CH2:21]1.P(Cl)(Cl)(Cl)=O>>[CH3:19][CH:20]1[N:24]=[C:23]([N:6]2[C:5]3[CH:4]=[C:3]([C:2]([F:1])([F:17])[F:18])[CH:16]=[CH:15][C:14]=3[O:13][C:12]3[C:7]2=[CH:8][CH:9]=[CH:10][CH:11]=3)[CH2:22][CH2:21]1

참가 물질

4

반응물 3

HCID 24813Phosphorus oxychlorideHCID 660555-Methyl-2-pyrrolidoneHCID 104673212-Trifluoromethylphenoxazine

생성물 1

HCID 2275425810-(5-Methyl-1-pyrrolin-2-YL)-2-(trifluoromethyl)phenoxazine

실험 절차

Reaction of 2-(trifluoromethyl)phenoxazine, 5-methyl-2-pyrrolidinone and phosphorous oxychloride according to the procedure of Example 1 provides the free base 10-(5-METHYL-1-PYRROLIN-2-YL)-2-(TRIFLUOROMETHYL)PHENOXAZINE as a distillable oil, b.p. 145-152° C. at 0.03 mm Hg. Conversion of the free base to the hydrochloride salt affords 10-(5-METHYL-1-PYRROLIN-2-YL)-2-(TRIFLUOROMETHYL)PHENOXAZINE HYDROCHLORIDE, m.p. 192.5-195.5° C. (dec.) (corr.), in a 45% overall yield.

출처 및 근거

ORD 기록
ord-2625e70668e54951a28c57e8ebc406d9
출처 데이터셋
uspto-grants-1979_01
특허 번호
US04132794

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