Hydrogen Bromide → HCID 20329310, compound

HRID 2163289Notes

Reaction equation

HRID 2163289 reaction equation
COC1C=CC(C[O:8][CH2:9][C:10]2[N:14]3[C:15]4[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][C:16]=4[N:17]([C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=4)[C:18](=[O:20])[CH2:19][C:13]3=[N:12][N:11]=2)=CC=1.Br.[OH-].[Na+]>C(O)(=O)C>[OH:8][CH2:9][C:10]1[N:14]2[C:15]3[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][C:16]=3[N:17]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[C:18](=[O:20])[CH2:19][C:13]2=[N:12][N:11]=1

Participants

5

Reactant 3

HCID 260Hydrogen BromideHCID 14798Sodium HydroxideHCID 20329357HCID 20329357, compound

Product 1

HCID 20329310HCID 20329310, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

3.1 g of 1-[(p-methoxybenzyloxy)-methyl]-8-chloro-6-phenyl-4H-s-triazolo[4,3-a][1,5]benzodiazepin-5-one in 30 ml acetic acid, at 25°, is stirred with 24 ml 48% aqueous hydrobromic acid for 20 minutes. The reaction is neutralized with 30% aqueous sodium hydroxide and extracted with chloroform. The organic phase is separated, washed with water, dried and the solvent evaporated to give the title compound.

Workup

  1. extractionextracted with chloroform
  2. customThe organic phase is separated
  3. washwashed with water
  4. customdried
  5. customthe solvent evaporated

Sources & evidence

ORD record
ord-43611d1c1a5249cb911f8b6a3e16c01e
Source dataset
uspto-grants-1979_01
Patent number
US04133809

Reaction notes

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