HCID 20329348, compound → HCID 20329341, compound

HRID 2163302Notes

Reaction equation

HRID 2163302 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][C:15]2[N:19]3[C:20]4[CH:35]=[CH:34][C:33]([Cl:36])=[CH:32][C:21]=4[N:22]([C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=4)[C:23](=[O:25])[CH2:24][C:18]3=[N:17][N:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C>FC(F)(F)C(O)=O>[N:11]1([CH2:14][C:15]2[N:19]3[C:20]4[CH:35]=[CH:34][C:33]([Cl:36])=[CH:32][C:21]=4[N:22]([C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=4)[C:23](=[O:25])[CH2:24][C:18]3=[N:17][N:16]=2)[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

Participants

3

Reactant 1

HCID 20329348HCID 20329348, compound

Product 1

HCID 20329341HCID 20329341, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

2 g. of 1-[4-(t-butoxycarbonyl)-piperazinomethyl]-8-chloro-6-phenyl-4-H-s-triazolo[4,3-a][1,5]benzodiazepin-5-one in 50 ml of trifluoroacetic acid is stirred for 2 hours. The reaction mixture is evaporated and the residue partitioned between methylene chloride and aqueous sodium bicarbonate. The organic phase is washed with water, dried and evaporated to give the title compound.

Workup

  1. customThe reaction mixture is evaporated
  2. customthe residue partitioned between methylene chloride and aqueous sodium bicarbonate
  3. washThe organic phase is washed with water
  4. customdried
  5. customevaporated

Sources & evidence

ORD record
ord-2b49a33f5c5e4056a92f182658ab4f1b
Source dataset
uspto-grants-1979_01
Patent number
US04133809

Reaction notes

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