Triethylamine → HCID 21333332, compound

HRID 2163339Notes

Reaction equation

HRID 2163339 reaction equation
C([CH2:3][O:4][C:5](=[O:31])[C:6]1[CH:11]=[CH:10][C:9]([C:12]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:8][N:7]=1)#N.C(N(CC)CC)C>CO>[C:25]1([C:12]([C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)([C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[C:9]2[CH:10]=[CH:11][C:6]([C:5]([O:4][CH3:3])=[O:31])=[N:7][CH:8]=2)[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1

Participants

4

Reactant 2

HCID 8471TriethylamineHCID 21333313HCID 21333313, compound

Product 1

HCID 21333332HCID 21333332, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

Heat at reflux 4 gm. (0.01 mole) of cyanomethyl-5-(triphenylmethyl)picolinate and 2 ml. triethylamine in 50 ml. methanol for 4 hr. Remove methanol under reduced pressure. Triturate solid residue with water and recrystallize from ethylacetate - isopropyl ether, to obtain the product of this example, m.p. 160°-164°.

Workup

  1. temperatureHeat
  2. temperatureat reflux 4 gm
  3. customTriturate solid residue with water
  4. customrecrystallize from ethylacetate - isopropyl ether
  5. customto obtain the product of this example, m.p. 160°-164°

Sources & evidence

ORD record
ord-12c94a8cf9e14b369832387583df8ba2
Source dataset
uspto-grants-1979_01
Patent number
US04133887

Reaction notes

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