Diethanolamine → Picotrin diolamine

HRID 2163342Notes

Reaction equation

HRID 2163342 reaction equation
[C:1]1([C:7]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:8]2[CH:9]=[CH:10][C:11]([C:14]([OH:16])=[O:15])=[N:12][CH:13]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH:29]([CH2:33][CH2:34][OH:35])[CH2:30][CH2:31][OH:32]>C(O)C>[NH:29]([CH2:33][CH2:34][OH:35])[CH2:30][CH2:31][OH:32].[C:23]1([C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)([C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)[C:8]2[CH:9]=[CH:10][C:11]([C:14]([OH:16])=[O:15])=[N:12][CH:13]=2)[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1

Participants

4

Reactant 2

HCID 8113DiethanolamineHCID 47264picotrin

Product 1

HCID 20055536Picotrin diolamine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Combine 5.5 g. of 5-(triphenylmethyl)-picolinic acid and 1.6 g. of diethanolamine in 200 ml. of ethanol and heat to form a solution, then cool to precipitate the salt. Recrystallize from ethanol to give the title compound, m.p. 206-209° .

Workup

  1. customto form a solution
  2. temperaturecool
  3. customto precipitate the salt
  4. customRecrystallize from ethanol

Sources & evidence

ORD record
ord-c4cc0a53b174427b9f14b29c38479169
Source dataset
uspto-grants-1979_01
Patent number
US04133887

Reaction notes

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