HRID2163352

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6363

Isopropylamine

C3H9N

结构：CC1(C)CC(c2ccccc2)c2ccc(OCC3CO3)cc2O1

HCID23330756

未命名化合物

PRODUCTS

生成物

结构：CC(C)NCC(O)COc1ccc2c(c1)OC(C)(C)CC2c1ccccc1

HCID3046430

未命名化合物

收率 73%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

A mixture of 7-(2,3-epoxypropoxy)-2,2-dimethyl-4-phenylchroman (6.35g.), isopropylamine (16ml) and ethanol (16ml) was boiled under reflux for 2 days. Removal of the solvent in vacuo gave 7-(2-hydroxy-3-isopropylaminopropoxy)-2,2-dimethyl-4-phenylchroman (6.7g., 73%) isolated as the hydrochloride salt, m.p. 171-174° from ether-ethanol.

WORKUP

后处理

temperatureunder reflux for 2 days
customRemoval of the solvent in vacuo