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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2163352Generated: October 31, 2026

Isopropylamine → 7-(2-Hydroxy-3-isopropylaminopropoxy)-2,2-dimethyl-4-phenylchroman

https://huagongshe.com/reaction/2163352

Reaction equation

Participants

RoleNameHCIDCharge
ReactantIsopropylamineHCID 6363—
Reactant7-(2,3-Epoxypropoxy)-2,2-dimethyl-4-phenylchromanHCID 23330756—
SolventEthanolHCID 702—
Product7-(2-Hydroxy-3-isopropylaminopropoxy)-2,2-dimethyl-4-phenylchromanHCID 304643073%

Reaction Steps

A mixture of 7-(2,3-epoxypropoxy)-2,2-dimethyl-4-phenylchroman (6.35g.), isopropylamine (16ml) and ethanol (16ml) was boiled under reflux for 2 days. Removal of the solvent in vacuo gave 7-(2-hydroxy-3-isopropylaminopropoxy)-2,2-dimethyl-4-phenylchroman (6.7g., 73%) isolated as the hydrochloride salt, m.p. 171-174° from ether-ethanol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04133883
Source datasetuspto-grants-1979_01
ORD IDord-42b4017bd2844a97b2c609bec820c2c8
Source noteuspto-grants-1979_01