HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethyl Sulfate → 1-Bromo-2-fluoro-4-methoxybenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethyl Sulfate | HCID 6497 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Bromo-3-fluorophenol | HCID 2779153 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 1-Bromo-2-fluoro-4-methoxybenzene | HCID 3718444 | — |
Reaction Steps
To 1-bromo-2-fluoro-4-hydroxybenzene (100 g, 0.52 mol) and K2CO3 (179.4 g, 1.3 mol) in 1300 mL acetone was added dimethyl sulfate (98.38 g, 0.78 mol). After refluxing overnight, the reaction mixture was cooled, filtered and dried over Na2SO4, and the filtrate was concentrated to afford 1-bromo-2-fluoro-4-methoxybenzene as a brown oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08193228B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-1bb0054a91a148f091fae3899c7b253f |
| Source note | uspto-grants-2012_06 |