反应详情

To 1-bromo-2-fluoro-4-hydroxybenzene (100 g, 0.52 mol) and K2CO3 (179.4 g, 1.3 mol) in 1300 mL acetone was added dimethyl sulfate (98.38 g, 0.78 mol). After refluxing overnight, the reaction mixture was cooled, filtered and dried over Na2SO4, and the filtrate was concentrated to afford 1-bromo-2-fluoro-4-methoxybenzene as a brown oil.

1. temperatureAfter refluxing overnight
2. temperaturethe reaction mixture was cooled
3. filtrationfiltered
4. dry with materialdried over Na2SO4
5. concentrationthe filtrate was concentrated