反应详情

To a stirred solution of methyl-lithium in ether (60ml, 2M solution) at room temperature was added over 0.5 hours 7-hydroxy-4-(1-naphthyl)coumarin (7.5g, 0.025 moles). The reaction mixture was refluxed for 2 hours, allowed to cool and decomposed by the addition of dilute hydrochloric acid. The organic layer was separated, the aqueous layer extracted with ether (2x) and the combined organic extracts washed with water and dried. Removal of solvent gave the required title chromene as an orange oil (7.22g, 95%).

1. temperatureThe reaction mixture was refluxed for 2 hours
2. temperatureto cool
3. customThe organic layer was separated
4. extractionthe aqueous layer extracted with ether (2x)
5. washthe combined organic extracts washed with water
6. customdried
7. customRemoval of solvent