HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 4-(2,2-dimethylpropyl)-N,N-dimethyl-1H-imidazole-1-sulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Dimethylsulphamoyl chloride | HCID 83372 | — |
| Reactant | HCID 20361665 | HCID 20361665 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-(2,2-dimethylpropyl)-N,N-dimethyl-1H-imidazole-1-sulfonamide | HCID 59140396 | — |
Reaction Steps
A solution of 5-(2,2-dimethylpropyl)-1H-imidazole, dimethylsulfamoyl chloride (25 mL), Et3N (45 mL) in CH2Cl2 (300 mL) was added DMAP (0.8 g). The reaction mixture was refluxed overnight. The solvent was evaporated and the residue was purified by silica gel chromatography to give the title compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08193228B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-fce201cbc7b94f32b75c1ac10287c823 |
| Source note | uspto-grants-2012_06 |