Triethylamine → 4-(2,2-dimethylpropyl)-N,N-dimethyl-1H-imidazole-1-sulfonamide

HRID 216346Notes

Reaction equation

HRID 216346 reaction equation
[CH3:1][C:2]([CH3:10])([CH3:9])[CH2:3][C:4]1[NH:8][CH:7]=[N:6][CH:5]=1.[CH3:11][N:12]([CH3:17])[S:13](Cl)(=[O:15])=[O:14].CCN(CC)CC>C(Cl)Cl.CN(C1C=CN=CC=1)C>[CH3:1][C:2]([CH3:10])([CH3:9])[CH2:3][C:4]1[N:8]=[CH:7][N:6]([S:13]([N:12]([CH3:17])[CH3:11])(=[O:15])=[O:14])[CH:5]=1

Participants

6

Reactant 3

HCID 8471TriethylamineHCID 83372Dimethylsulphamoyl chlorideHCID 20361665HCID 20361665, compound

Product 1

HCID 591403964-(2,2-dimethylpropyl)-N,N-dimethyl-1H-imidazole-1-sulfonamide

Reagents, catalysts & solvents 2

HCID 142844-(Dimethylamino)pyridineCatalystHCID 6344DichloromethaneSolvent

Procedure

A solution of 5-(2,2-dimethylpropyl)-1H-imidazole, dimethylsulfamoyl chloride (25 mL), Et3N (45 mL) in CH2Cl2 (300 mL) was added DMAP (0.8 g). The reaction mixture was refluxed overnight. The solvent was evaporated and the residue was purified by silica gel chromatography to give the title compound as a white solid.

Workup

  1. temperatureThe reaction mixture was refluxed overnight
  2. customThe solvent was evaporated
  3. customthe residue was purified by silica gel chromatography

Sources & evidence

ORD record
ord-fce201cbc7b94f32b75c1ac10287c823
Source dataset
uspto-grants-2012_06
Patent number
US08193228B2

Reaction notes

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