Sodium Chloride → HCID 86736247, compound

Participants

Reaction Steps

10 parts by weight sodium chloride, 7.5 parts by weight mannitol, 8.0 parts by weight Polywax 5/6000, 2.5 parts by weight Kollidon VA 64 and 2.0 parts by weight sodium alginate are dissolved in warm water and sprayed in the form of a 30% solution, at a pressure of 3.0 atmospheres, through an injection needle (No. 12) into liquid nitrogen. The frozen, readily flowable granulate obtained, with a water content of 70% by weight, is tabletted in the form of ice at -20 to -25° C in a pre-cooled tabletting press. The granulate can be pressed without any melting effect or sticking taking place. The tablets obtained are dried in a desiccator over a drying agent or by lyophilization.

Provenance & Evidence