1,2-Dibromoethane → 1-(6,7-dimethoxy-4(3H)-quinazolinone-3-yl)-2-bromoethane

HRID 2163534Notes

Reaction equation

HRID 2163534 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][NH:7][C:6]2=[O:15].[Br:16][CH2:17][CH2:18]Br.C(Cl)(Cl)Cl.CO>CN(C)C=O>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][N:7]([CH2:18][CH2:17][Br:16])[C:6]2=[O:15]

Participants

5

Reactant 3

HCID 78391,2-DibromoethaneHCID 21584188Chloroform methanolHCID 1354950166,7-Dimethoxy-3H-quinazolin-4-one

Product 1

HCID 227527841-(6,7-dimethoxy-4(3H)-quinazolinone-3-yl)-2-bromoethane

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

1-(6,7-Dimethoxy-4(3H)-quinazolinone-3-yl)-2-bromo-ethane was prepared analogous to Example 1 (a) by reaction of 6,7-dimethoxy-4(3H)-quinazolinone with 1,2-dibromoethane in dimethylformamide. Viscous oil. Rf -value (chloroform/methanol = 9/1) : 0.85.

Sources & evidence

ORD record
ord-50b40678bfc24bd186b36179b8a85127
Source dataset
uspto-grants-1979_01
Patent number
US04134980

Reaction notes

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