Chlorobenzene → 1-(6,7-dimethoxy-4(3H)-quinazolinone-3-yl)-2-[N-methyl-N-(2-(3,4-dimethoxy-phenyl)-ethyl)-amino]-ethane hydrochloride
Reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][N:7]([CH2:15][CH2:16]Br)[C:6]2=[O:18].[CH3:19][O:20][C:21]1[CH:22]=[C:23]([CH2:29][CH2:30][NH:31][CH3:32])[CH:24]=[CH:25][C:26]=1[O:27][CH3:28].[Cl:33]C1C=CC=CC=1>>[ClH:33].[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][N:7]([CH2:15][CH2:16][N:31]([CH3:32])[CH2:30][CH2:29][C:23]1[CH:24]=[CH:25][C:26]([O:27][CH3:28])=[C:21]([O:20][CH3:19])[CH:22]=1)[C:6]2=[O:18]Participants
4
Procedure
1-(6,7-dimethoxy-4(3H)-quinazolinone-3-yl)-2-[N-methyl-N-(2-(3,4-dimethoxy-phenyl)-ethyl)-amino]-ethane hydrochloride was prepared analogous to Example 1 (b) by reaction of 1-(6,7-dimethoxy-4(3H)-quinazolinone-3-yl)-2-bromoethane with N-(3,4-dimethoxy-phenyl ethyl)-N-methyl amine in chlorobenzene. M.p.: 205 - 208° C.
Sources & evidence
- ORD record
- ord-bc8cecd0257c4fa6936fbe955f2272b2
- Source dataset
- uspto-grants-1979_01
- Patent number
- US04134980
Reaction notes
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