Hydrochloric Acid → HCID 22750628, compound

HRID 2163622Notes

Reaction equation

HRID 2163622 reaction equation
N[C:2](=[C:9]([C:14](=[O:24])[CH2:15][CH:16]([OH:23])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[C:10]([NH:12][CH3:13])=[O:11])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.Cl.CCOCC>C(O)C>[C:3]1([C:2]2[O:23][CH:16]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[CH2:15][C:14](=[O:24])[C:9]=2[C:10]([NH:12][CH3:13])=[O:11])[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 178485723HCID 178485723, compound

Product 1

HCID 22750628HCID 22750628, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 21.4 grams (0.066 mole) of 2-(α-aminobenzylidene)-5-hydroxy-N-methyl-3-oxo-5-phenylvaleramide in 220 milliliters of ethanol is treated by dropwise addition with 10 milliliters of concentrated hydrochloric acid. The resulting suspension is stirred for 1.5 hours at room temperature. Ether is then added, and the mixture is filtered. The resulting solid is triturated thoroughly with hot methanol to give 5,6-dihydro-2,6-diphenyl-N-methyl-4-oxo-4H-pyran-3-carboxamide, m.p. 212° C.-214° C.

Workup

  1. filtrationthe mixture is filtered
  2. customThe resulting solid is triturated thoroughly with hot methanol

Sources & evidence

ORD record
ord-f3787e1fa9b544b59d383d02afef33a9
Source dataset
uspto-grants-1979_01
Patent number
US04136114

Reaction notes

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