3-Chloro-6-(methylthio)pyridazine → HCID 178503271, compound

HRID 2163658Notes

Reaction equation

HRID 2163658 reaction equation
Cl[C:2]1[N:3]=[N:4][C:5]([S:8][CH3:9])=[CH:6][CH:7]=1.C([O-])(=[O:12])C.[Na+]>C(O)(=O)C>[OH:12][C:2]1[N:3]=[N:4][C:5]([S:8][CH3:9])=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 2524753-Chloro-6-(methylthio)pyridazineHCID 517045Sodium Acetate

Product 1

HCID 178503271HCID 178503271, compoundYield 65.4%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 96 g (0.6 mol) of 3-chloro-6-methylthiopyridazine and 98.4 g (1.2 mols) of sodium acetate in 500 ml of glacial acetic acid was boiled for 2 hours under reflux. The solvent was then distilled off in vacuo, the residue was triturated with water and the reaction product was filtered off. In this way, 55.8 g (65% of theory) of 3-hydroxy-6-methylthiopyridazine were obtained in the form of a beige powder of melting point 119° C.

Workup

  1. temperatureunder reflux
  2. distillationThe solvent was then distilled off in vacuo
  3. customthe residue was triturated with water
  4. filtrationthe reaction product was filtered off

Sources & evidence

ORD record
ord-674a86817ca746cc97bef39a0c414f1a
Source dataset
uspto-grants-1979_01
Patent number
US04136176

Reaction notes

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