Ethyl formate → HCID 22751278, compound

HRID 2163676Notes

Reaction equation

HRID 2163676 reaction equation
[C:1]1([CH:7]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:8][C:9]2[NH:10][CH2:11][CH2:12][N:13]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:20]([O:22]C=O)C>>[CH:20]([N:13]1[CH2:12][CH2:11][N:10]=[C:9]1[CH2:8][CH:7]([C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1)=[O:22]

Participants

3

Reactant 2

HCID 8025Ethyl formate2×HCID 12632114HCID 12632114, compound

Product 1

HCID 22751278HCID 22751278, compound

Procedure

a mixture of 2.5 g of 2-(2,2-diphenyl ethyl)-2-imidazoline and 50 ml of ethylformate was refluxed for 5 hours. After the reaction, unreacted ethylformate was removed by distillation. The resulting residue was subjected to silica gel column chromatography and eluted with methylene chloride. The solvent was removed by distillation from the eluate to give 1.2 g of 1-formyl-2-(2,2-diphenyl ethyl)-2-imidazoline having a melting point of 105° to 107° C.

Workup

  1. temperaturewas refluxed for 5 hours
  2. customwas removed by distillation
  3. washeluted with methylene chloride
  4. customThe solvent was removed by distillation from the eluate

Sources & evidence

ORD record
ord-c0050035abe549d0880b1124da63fb69
Source dataset
uspto-grants-1979_01
Patent number
US04136188

Reaction notes

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