HRID2163762

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID222872

4-tert-Butylbenzenesulfonamide

C10H15NO2S

结构：CCCCCCCCCCCCCCCCNc1ccc(C(=O)Cl)cc1.Cl

HCID13255322

未命名化合物

PRODUCTS

生成物

结构：CCCCCCCCCCCCCCCCNc1ccc(C(=O)NS(=O)(=O)c2ccc(C(C)(C)C)cc2)cc1

HCID20437349

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID1049

Pyridine

C5H5N

PROCEDURE

实验过程

A solution of 21.1 g. of 4-(hexadecylamino)benzoyl chloride hydrochloride and 10.8 g. of p-tert-butylbenzenesulfonamide in 250 ml. of pyridine was stirred under reflux for 2 hours and evaporated. The residue was partitioned between 1N hydrochloric acid and CH2Cl2 and the organic layer was separated, washed with water, dried (MgSO4), and evaporated. Crystallization of the residual glass from CH2Cl2 hexane afforded a white solid, melting point 173°-176° C.

WORKUP

后处理

temperatureunder reflux for 2 hours
customevaporated
customThe residue was partitioned between 1N hydrochloric acid and CH2Cl2
customthe organic layer was separated
washwashed with water
dry with materialdried (MgSO4)
customevaporated
customCrystallization of the residual glass from CH2Cl2 hexane
customafforded a white solid, melting point 173°-176° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f5471b222d6e40188886a9c207516c5f
来源数据集: uspto-grants-1979_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04136256
来源说明: uspto-grants-1979_01

反应 SMILES

Cl.[CH2:2]([NH:18][C:19]1[CH:27]=[CH:26][C:22]([C:23](Cl)=[O:24])=[CH:21][CH:20]=1)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17].[C:28]([C:32]1[CH:37]=[CH:36][C:35]([S:38]([NH2:41])(=[O:40])=[O:39])=[CH:34][CH:33]=1)([CH3:31])([CH3:30])[CH3:29]>N1C=CC=CC=1>[CH2:2]([NH:18][C:19]1[CH:27]=[CH:26][C:22]([C:23]([NH:41][S:38]([C:35]2[CH:36]=[CH:37][C:32]([C:28]([CH3:31])([CH3:30])[CH3:29])=[CH:33][CH:34]=2)(=[O:39])=[O:40])=[O:24])=[CH:21][CH:20]=1)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17]