Hydrochloric Acid → HCID 178442460, compound

HRID 216379Notes

Reaction equation

HRID 216379 reaction equation
Cl.[CH3:2][C:3]([CH3:48])([CH2:46][CH3:47])[CH2:4][C:5]1[N:6]=[C:7]([CH2:29][CH:30]([C:33]2[CH:38]=[CH:37][C:36]([C:39]3[CH:44]=[CH:43][C:42]([F:45])=[CH:41][N:40]=3)=[CH:35][CH:34]=2)[O:31][CH3:32])[N:8](C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[CH:9]=1>CO>[CH3:2][C:3]([CH3:48])([CH2:46][CH3:47])[CH2:4][C:5]1[N:6]=[C:7]([CH2:29][CH:30]([C:33]2[CH:38]=[CH:37][C:36]([C:39]3[CH:44]=[CH:43][C:42]([F:45])=[CH:41][N:40]=3)=[CH:35][CH:34]=2)[O:31][CH3:32])[NH:8][CH:9]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 686676522-(4-{2-[4-(2,2-dimethylbutyl)-1-trityl-1H-imidazol-2-yl]-1-methoxyethyl}phenyl)-5-fluoropyridine

Product 1

HCID 178442460HCID 178442460, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
70 °C

Procedure

Hydrochloric acid (2N, 4 mL) was added to a solution of 2-(4-{2-[4-(2,2-dimethylbutyl)-1-trityl-1H-imidazol-2-yl]-1-methoxyethyl}phenyl)-5-fluoropyridine in methanol (4 mL) at ambient temperature. The solution was stirred at 70° C. for 2 hr. Concentration of the solution afforded the title compound as a white solid. 1H NMR (500 MHz, CD3OD) δ 8.66-8.60 (m, 1H), 8.05-7.83 (m, 5H), 7.45-7.37 (m, 2H), 7.16 (s, 1H), 4.72-4.68 (m, 1H), 3.28 (s, 3H), 2.51 (s, 2H), 1.28-1.20 (m, 2H), 0.86 (t, J=7.0 Hz, 3H), 0.83 (s, 6H).

Sources & evidence

ORD record
ord-02cec69cb9384808a409905fa3f29751
Source dataset
uspto-grants-2012_06
Patent number
US08193228B2

Reaction notes

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