Hydrochloric Acid → HCID 20437367, compound

HRID 2163790Notes

Reaction equation

HRID 2163790 reaction equation
FC(F)(F)C([N:5]([C:22]1[CH:41]=[CH:40][C:25]([C:26]([NH:28][C:29]2[CH:39]=[CH:38][C:32]([C:33]([O:35]CC)=[O:34])=[CH:31][CH:30]=2)=[O:27])=[CH:24][CH:23]=1)[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])=O.C(O)C.[OH-].[Na+].Cl>O>[CH2:6]([NH:5][C:22]1[CH:41]=[CH:40][C:25]([C:26]([NH:28][C:29]2[CH:39]=[CH:38][C:32]([C:33]([OH:35])=[O:34])=[CH:31][CH:30]=2)=[O:27])=[CH:24][CH:23]=1)[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14798Sodium HydroxideHCID 20437363HCID 20437363, compound

Product 1

HCID 20437367HCID 20437367, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a stirred solution of 3.62 g. of ethyl p-[p-(2,2,2-trifluoro-N-hexadecylacetamido)benzamido]benzoate in 72 ml. of ethanol was added a solution of 1.44 g. of sodium hydroxide in 18 ml. of water and the resulting mixture was heated under reflux for 30 min. The mixture was allowed to cool, acidified with dilute hydrochloric acid, and filtered. The white solid was recrystallized from acetonitrile.

Workup

  1. temperatureunder reflux for 30 min
  2. temperatureto cool
  3. filtrationfiltered
  4. customThe white solid was recrystallized from acetonitrile

Sources & evidence

ORD record
ord-4487291606614492b6d4c154491a4c84
Source dataset
uspto-grants-1979_01
Patent number
US04136256

Reaction notes

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