2-chloro-N-methylacetamide → 2-(5-Hydroxy-7-isopropyl-10,10-dimethyl-1,2,4,10-tetrahydro-9-oxa-3-aza-phenanthren-3-yl)-N-methyl-acetamide

HRID 2163810Notes

Reaction equation

HRID 2163810 reaction equation
[OH:1][C:2]1[C:7]2[C:8]3[CH2:9][NH:10][CH2:11][CH2:12][C:13]=3[C:14]([CH3:17])([CH3:16])[O:15][C:6]=2[CH:5]=[C:4]([CH:18]([CH3:20])[CH3:19])[CH:3]=1.Cl[CH2:22][C:23]([NH:25][CH3:26])=[O:24]>>[OH:1][C:2]1[C:7]2[C:8]3[CH2:9][N:10]([CH2:22][C:23]([NH:25][CH3:26])=[O:24])[CH2:11][CH2:12][C:13]=3[C:14]([CH3:16])([CH3:17])[O:15][C:6]=2[CH:5]=[C:4]([CH:18]([CH3:20])[CH3:19])[CH:3]=1

Participants

3

Reactant 2

HCID 667732-chloro-N-methylacetamideHCID 2028786610-hydroxy-8-isopropyl-5,5-dimethyl-1,2,3,4-tetrahydro-5H-[1]benzopyrano[4,3-c]pyridine

Product 1

HCID 213211402-(5-Hydroxy-7-isopropyl-10,10-dimethyl-1,2,4,10-tetrahydro-9-oxa-3-aza-phenanthren-3-yl)-N-methyl-acetamide

Procedure

The above-titled compound was prepared by reacting 10-hydroxy-8-isopropyl-5,5-dimethyl-1,2,3,4-tetrahydro-5H-[1]benzopyrano[4,3-c]pyridine with 2-chloro-N-methylacetamide according to the method of Example 1; m.p. 178-190°.

Sources & evidence

ORD record
ord-4ada01923a79402ca036129ffe45a1a7
Source dataset
uspto-grants-1979_01
Patent number
US04137232

Reaction notes

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