Hydrochloric Acid → HCID 178442450, compound

HRID 216382Notes

Reaction equation

HRID 216382 reaction equation
Cl.[CH3:2][C:3]([CH3:47])([CH2:45][CH3:46])[CH2:4][C:5]1[N:6]=[C:7]([CH2:29][CH:30]([C:32]2[CH:37]=[CH:36][C:35]([C:38]3[CH:43]=[CH:42][C:41]([F:44])=[CH:40][N:39]=3)=[CH:34][CH:33]=2)[NH2:31])[N:8](C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[CH:9]=1>CO>[CH3:2][C:3]([CH3:47])([CH2:45][CH3:46])[CH2:4][C:5]1[N:6]=[C:7]([CH2:29][CH:30]([C:32]2[CH:37]=[CH:36][C:35]([C:38]3[CH:43]=[CH:42][C:41]([F:44])=[CH:40][N:39]=3)=[CH:34][CH:33]=2)[NH2:31])[NH:8][CH:9]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 686682132-[4-(2,2-dimethylbutyl)-1-trityl-1H-imidazol-2-yl]-1-[4-(5-fluoropyridin-2-yl)phenyl]ethanamine

Product 1

HCID 178442450HCID 178442450, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
60 °C

Procedure

Hydrogen chloride (4 M in dioxane) (2 mL, 0.5 mmol) was added to a solution of 2-[4-(2,2-dimethylbutyl)-1-trityl-1H-imidazol-2-yl]-1-[4-(5-fluoropyridin-2-yl)phenyl]ethanamine (20 mg, 0.03 mmol) in methanol (6 mL). After stirring at 60° C. for 1 h, volatiles were removed. The residue was purified by preparative HPLC eluting with 10-50% acetonitrile/water and lyophilized to afford the title compound. (M+H) found 367.

Workup

  1. customvolatiles were removed
  2. customThe residue was purified by preparative HPLC
  3. washeluting with 10-50% acetonitrile/water

Sources & evidence

ORD record
ord-efc5bd990e3949a3a8f8b440085f15c6
Source dataset
uspto-grants-2012_06
Patent number
US08193228B2

Reaction notes

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