Water → HCID 22750091, compound

HRID 2164048Notes

Reaction equation

HRID 2164048 reaction equation
C(O[C:4]1[C:13]2[CH:12]=[CH:11][CH:10]=[C:9]3[N:14]4[C:18]([C:19](=[O:20])[C:7]([C:8]=23)=[CH:6][N:5]=1)=[CH:17][CH:16]=[C:15]4[N+:21]([O-:23])=[O:22])C.O.[CH2:25]([N:27]([CH2:31][CH3:32])[CH2:28][CH2:29][NH2:30])[CH3:26]>>[CH2:25]([N:27]([CH2:31][CH3:32])[CH2:28][CH2:29][NH:30][C:4]1[C:13]2[CH:12]=[CH:11][CH:10]=[C:9]3[N:14]4[C:18]([C:19](=[O:20])[C:7]([C:8]=23)=[CH:6][N:5]=1)=[CH:17][CH:16]=[C:15]4[N+:21]([O-:23])=[O:22])[CH3:26]

Participants

4

Reactant 3

HCID 962WaterHCID 60993N,N-DiethylethylenediamineHCID 22750105HCID 22750105, compound

Product 1

HCID 22750091HCID 22750091, compound

Procedure

A solution of 4-ethoxy-10-nitro-7-oxo-7H-indolizino[7,6,5-de]isoquinoline (4.45 g) in N,N-diethylethylenediamine (67 cc) is stirred at a temperature of about 20° C. After stirring for 5 minutes, crystals are formed. The mixture is stirred for a further 40 minutes and the dark red suspension thus obtained is then poured into iced water (335 cc). After filtering off the crystals, they are washed with water (3 × 10 cc) and then dried under reduced pressure (1 mm Hg) at 50° C. Crude 4-(2-diethylaminoethylamino)-10-nitro-7-oxo-7H-indolizino[7,6,5-de]isoquinoline (4.20 g) is thus obtained.

Workup

  1. customcrystals are formed
  2. stirringThe mixture is stirred for a further 40 minutes
  3. customthe dark red suspension thus obtained
  4. filtrationAfter filtering off the crystals, they
  5. washare washed with water (3 × 10 cc)
  6. customdried under reduced pressure (1 mm Hg) at 50° C

Sources & evidence

ORD record
ord-99be61a04d594d63a10e2f143173aaab
Source dataset
uspto-grants-1979_01
Patent number
US04137315

Reaction notes

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