Water → HCID 22750091, compound

Participants

Reaction Steps

A solution of 4-ethoxy-10-nitro-7-oxo-7H-indolizino[7,6,5-de]isoquinoline (4.45 g) in N,N-diethylethylenediamine (67 cc) is stirred at a temperature of about 20° C. After stirring for 5 minutes, crystals are formed. The mixture is stirred for a further 40 minutes and the dark red suspension thus obtained is then poured into iced water (335 cc). After filtering off the crystals, they are washed with water (3 × 10 cc) and then dried under reduced pressure (1 mm Hg) at 50° C. Crude 4-(2-diethylaminoethylamino)-10-nitro-7-oxo-7H-indolizino[7,6,5-de]isoquinoline (4.20 g) is thus obtained.

Provenance & Evidence