Bromine → HCID 22750135, compound

HRID 2164054Notes

Reaction equation

HRID 2164054 reaction equation
[Br:1]Br.[C:3]([C:6]1[CH:7]=[C:8]([CH:18]=[CH:19][CH:20]=1)[NH:9][C:10]([C:12]1[CH:16]=[C:15]([CH3:17])[O:14][N:13]=1)=[O:11])(=[O:5])[CH3:4]>C(Cl)(Cl)Cl.C(OCC)C>[Br:1][CH2:4][C:3]([C:6]1[CH:7]=[C:8]([CH:18]=[CH:19][CH:20]=1)[NH:9][C:10]([C:12]1[CH:16]=[C:15]([CH3:17])[O:14][N:13]=1)=[O:11])=[O:5]

Participants

5

Reactant 2

HCID 24408BromineHCID 2555322HCID 2555322, compound

Product 1

HCID 22750135HCID 22750135, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6212ChloroformSolvent2×

Procedure

A solution of bromine (12.5 g) in chloroform (60 ml) was added to a slurry of 3'-acetyl-5-methyl-3-isoxazolecarboxanilide. 1/4 hydrate (19 g) in chloroform (190 ml). The mixture was stirred for 1/2 hour and diluted with diethyl ether. The product was filtered and dried. Yield 21.0 g = (84%,) m.p. 172°-174°.

Workup

  1. filtrationThe product was filtered
  2. customdried

Sources & evidence

ORD record
ord-1f4f2d4264a44f2a8eb9dfe8a62cbcdd
Source dataset
uspto-grants-1979_01
Patent number
US04137321

Reaction notes

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