HCID 21527340, compound → HCID 53668716, compound

HRID 2164071Notes

Reaction equation

HRID 2164071 reaction equation
[CH2:1]([O:3][C:4](=[O:25])[C:5]([NH:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([O:14]CC2C=CC=CC=2)[C:9]=1[C:22]([NH2:24])=[O:23])=[O:6])[CH3:2].[H][H]>[Pd]>[CH2:1]([O:3][C:4](=[O:25])[C:5]([NH:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([OH:14])[C:9]=1[C:22]([NH2:24])=[O:23])=[O:6])[CH3:2]

Participants

4

Reactant 2

HCID 21527340HCID 21527340, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 53668716HCID 53668716, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

A mixture of 3.4 g. of [2-(aminocarbonyl)-3-benzyloxyphenylamino]oxoacetic acid ethyl ester and 0.3 g. of 5% Pd on charcoal is hydrogenated until hydrogen uptake ceases. The mixture is filtered through celite; the filtrate is evaporated and the residue is recrystallized to give pure product, m.p. 200°-202° C.

Workup

  1. additionA mixture of 3.4 g
  2. filtrationThe mixture is filtered through celite
  3. customthe filtrate is evaporated
  4. customthe residue is recrystallized
  5. customto give pure product, m.p. 200°-202° C.

Sources & evidence

ORD record
ord-65fc44bf19904f07b36c4fde02f56c24
Source dataset
uspto-grants-1979_01
Patent number
US04137325

Reaction notes

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