Dimethylformamide → HCID 178433679, compound

HRID 2164085Notes

Reaction equation

HRID 2164085 reaction equation
[N:1]#[C:2][NH2:3].[Pb].[CH3:5][C:6]1[NH:10][CH:9]=[N:8][C:7]=1[CH2:11][S:12][CH2:13][CH2:14][NH:15][C:16](=S)[NH:17][CH2:18][CH2:19][CH2:20][NH:21][C:22]([NH:24][CH2:25][CH2:26][S:27][CH2:28][C:29]1[N:30]=[CH:31][NH:32][C:33]=1[CH3:34])=S.C[N:37]([CH3:40])C=O.C(#[N:43])C>>[C:2]([N:3]=[C:22]([NH:24][CH2:25][CH2:26][S:27][CH2:28][C:29]1[N:30]=[CH:31][NH:32][C:33]=1[CH3:34])[NH:21][CH2:20][CH2:19][CH2:18][NH:17][C:16]([NH:15][CH2:14][CH2:13][S:12][CH2:11][C:7]1[N:8]=[CH:9][NH:10][C:6]=1[CH3:5])=[N:43][C:40]#[N:37])#[N:1]

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 6342AcetonitrileHCID 22262466CH2N2PbHCID 537592711,3-bis-[N'-(2-(5-methyl-4-imidazolylmethylthio)ethyl)thioureido] propane

Product 1

HCID 178433679HCID 178433679, compound

Procedure

Lead cyanamide (3.0 g) was added to 1,3-bis-[N'-(2-(5-methyl-4-imidazolylmethylthio)ethyl)thioureido]propane (2.5 g) in acetonitrile. Dimethylformamide was added and the mixture was stirred and boiled under reflux for 24 hours. The mixture was filtered, concentrated and purified by chromatography to give the title compound.

Workup

  1. temperatureunder reflux for 24 hours
  2. filtrationThe mixture was filtered
  3. concentrationconcentrated
  4. custompurified by chromatography

Sources & evidence

ORD record
ord-9cbf49087bed4105b7d10bfa3ef10bd3
Source dataset
uspto-grants-1979_01
Patent number
US04137319

Reaction notes

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