2-Amino-5-methylthiazole → HCID 54684977, compound

HRID 2164091Notes

Reaction equation

HRID 2164091 reaction equation
[CH3:1][N:2]1[C:15]([C:16]([O:18]C)=O)=[C:14]([OH:20])[C:5]2[N:6]([CH3:13])[C:7]3[CH:8]=[CH:9][CH:10]=[CH:11][C:12]=3[C:4]=2[S:3]1(=[O:22])=[O:21].[NH2:23][C:24]1[S:25][C:26]([CH3:29])=[CH:27][N:28]=1>>[CH3:1][N:2]1[C:15]([C:16]([NH:23][C:24]2[S:25][C:26]([CH3:29])=[CH:27][N:28]=2)=[O:18])=[C:14]([OH:20])[C:5]2[N:6]([CH3:13])[C:7]3[CH:8]=[CH:9][CH:10]=[CH:11][C:12]=3[C:4]=2[S:3]1(=[O:22])=[O:21]

Participants

3

Reactant 2

HCID 3517702-Amino-5-methylthiazoleHCID 54684931HCID 54684931, compound

Product 1

HCID 54684977HCID 54684977, compoundYield 90%

Procedure

2,5-Dihydro-2,5-dimethyl-4-hydroxy-N-(5-methyl-2-thiazolyl)-1,2-thiazino[5,6-b]indole-3-carboxamide-1,1-dioxide was prepared analogous to Example 1 from methyl 2,5-Dihydro-2, 5-dimethyl-4-hydroxy-1,2-thiazino[5,6-b]indole-3-carboxylate 1,1-dioxide and 2-amino-5-methyl-thiazole with a yield of 90% of theory; M.p.: 250° C. (decomposition).

Sources & evidence

ORD record
ord-243266a94a7743dea03e5d92b958e578
Source dataset
uspto-grants-1979_01
Patent number
US04137313

Reaction notes

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