2-Amino-4-methylthiazole → HCID 54684963, compound

HRID 2164101Notes

Reaction equation

HRID 2164101 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:8]2[N:7]([CH3:11])[C:6]3[C:12]([OH:23])=[C:13]([C:19]([O:21]C)=O)[N:14]([CH3:18])[S:15](=[O:17])(=[O:16])[C:5]=3[C:4]=2[CH:3]=1.[NH2:24][C:25]1[S:26][CH:27]=[C:28]([CH3:30])[N:29]=1>>[Cl:1][C:2]1[CH:10]=[CH:9][C:8]2[N:7]([CH3:11])[C:6]3[C:12]([OH:23])=[C:13]([C:19]([NH:24][C:25]4[S:26][CH:27]=[C:28]([CH3:30])[N:29]=4)=[O:21])[N:14]([CH3:18])[S:15](=[O:16])(=[O:17])[C:5]=3[C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 741432-Amino-4-methylthiazoleHCID 54684967HCID 54684967, compound

Product 1

HCID 54684963HCID 54684963, compoundYield 81%

Procedure

8-Chloro-2,5-dihydro-2,5-dimethyl-4-hydroxy-N-(4-methyl-2-thiazolyl)-1,2-thiazino[5,6-b]indole-3-carboxamide-1,1-dioxide was prepared analogous to Example 18 from methyl 8-chloro-2,5-dihydro-2,5-dimethyl-4-hydroxy-1,2-thiazino[5,6-b]indole-3-carboxylate 1,1-dioxide and 2-amino-4-methyl-thiazole with a yield of 81% of theory.

Sources & evidence

ORD record
ord-42b4bd73e9d246bdb45b4422f9991180
Source dataset
uspto-grants-1979_01
Patent number
US04137313

Reaction notes

Loading…