Methyl iodide → HCID 54684932, compound

HRID 2164105Notes

Reaction equation

HRID 2164105 reaction equation
[OH:1][C:2]1[C:7]2[N:8]([CH3:17])[C:9]3[CH:10]=[CH:11][C:12]([O:15][CH3:16])=[CH:13][C:14]=3[C:6]=2[S:5](=[O:19])(=[O:18])[NH:4][C:3]=1[C:20]([O:22][CH3:23])=[O:21].[OH-].[Na+].[CH3:26]I>CO>[CH3:26][N:4]1[C:3]([C:20]([O:22][CH3:23])=[O:21])=[C:2]([OH:1])[C:7]2[N:8]([CH3:17])[C:9]3[CH:10]=[CH:11][C:12]([O:15][CH3:16])=[CH:13][C:14]=3[C:6]=2[S:5]1(=[O:19])=[O:18]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 14798Sodium HydroxideHCID 54684950HCID 54684950, compound

Product 1

HCID 54684932HCID 54684932, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

20.4 gm (60 millimols) of methyl 2,5-dihydro-4-hydroxy-8-methoxy-5-methyl-1,2-thiazino[5,6-b]indole-3-carboxylate 1,1-dioxide were reacted analogous to Example 18 (f) wtih a sodium hydroxide solution and methyl iodide in methanol to yield 17.9 gm (85% of theory) of methyl 2,5-dihydro-2,5-dimethyl-4-hydroxy-8-methoxy-1,2-thiazino[5,6-b]indole-3-carboxylate 1,1-dioxide; M.p.: 200°-201° C.

Sources & evidence

ORD record
ord-9e5c4ed68f6d45a991b302e330a9f900
Source dataset
uspto-grants-1979_01
Patent number
US04137313

Reaction notes

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