2-Aminothiazole → HCID 54684951, compound

HRID 2164115Notes

Reaction equation

[CH3:1][N:2]1[C:15]([C:16]([NH2:18])=[O:17])=[C:14]([OH:19])[C:5]2[N:6]([CH3:13])[C:7]3[CH:8]=[CH:9][CH:10]=[CH:11][C:12]=3[C:4]=2[S:3]1(=[O:21])=[O:20].N[C:23]1[S:24][CH:25]=[CH:26][N:27]=1>>[CH3:1][N:2]1[C:15]([C:16]([NH:18][C:23]2[S:24][CH:25]=[CH:26][N:27]=2)=[O:17])=[C:14]([OH:19])[C:5]2[N:6]([CH3:13])[C:7]3[CH:8]=[CH:9][CH:10]=[CH:11][C:12]=3[C:4]=2[S:3]1(=[O:21])=[O:20]

Participants

Reactant 2

HCID 21552-Aminothiazole

HCID 54684978HCID 54684978, compound

Product 1

HCID 54684951HCID 54684951, compoundYield 46%

Procedure

2,5-Dihydro-2,5-dimethyl-4-hydroxy-N-(2-thiazolyl)-1,2-thiazino-[5,6-b]indole-3-carboxamide-1,1-dioxide was prepared analogous to Example 36 from 2,5-dihydro-2,5-dimethyl-4-hydroxy-1,2-thiazino[5,6-b]indole-3-carboxamide-1,1-dioxide and 2-amino-thiazole with a yield of 46% of theory; M.p.: 260°-261° C. (decomp.).

Sources & evidence

ORD record: ord-fc7ebad0debb4a4fac7eee9527316d59
Source dataset: uspto-grants-1979_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04137313

Reaction notes

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