2-Aminothiazole → HCID 54684951, compound

HRID 2164116Notes

Reaction equation

[CH2:1]([NH:5][C:6]([C:8]1[N:9]([CH3:25])[S:10](=[O:24])(=[O:23])[C:11]2[C:19]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[N:13]([CH3:20])[C:12]=2[C:21]=1[OH:22])=[O:7])CCC.NC1[S:28][CH:29]=[CH:30][N:31]=1>>[CH3:25][N:9]1[C:8]([C:6]([NH:5][C:1]2[S:28][CH:29]=[CH:30][N:31]=2)=[O:7])=[C:21]([OH:22])[C:12]2[N:13]([CH3:20])[C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][C:19]=3[C:11]=2[S:10]1(=[O:24])=[O:23]

Participants

Reactant 2

HCID 21552-Aminothiazole

HCID 54684965HCID 54684965, compound

Product 1

HCID 54684951HCID 54684951, compoundYield 37%

Procedure

2,5-Dihydro-2,5-dimethyl-4-hydroxy-N-(2-thiazolyl)-1,2-thiazino-[5,6-b]indole-3-carboxamide-1,1-dioxide was prepared analogous to Example 36 from N-(n-butyl)-2,5-dihydro-2,5-dimethyl-4-hydroxy-1,2-thiazino[5,6-b]indole-3-carboxamide-1,1-dioxide and 2-amino-thiazole with a yield of 37% of theory; M.p.: 260°-261° C. (decomp.)

Sources & evidence

ORD record: ord-8d72485001de44d4b150188fef0432a6
Source dataset: uspto-grants-1979_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04137313

Reaction notes

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