Hydrogen Peroxide → HCID 20306499, compound

Participants

Reaction Steps

α-Methylthio(3-thienyl)acetic acid (1.487 g) was dissolved in 20 ml of methanol, and 10 mg of sodium tungstate and 2.5 ml of a 30% aqueous solution of hydrogen peroxide were added. The mixture was stirred for 3 days. To the reaction mixture was added 50 ml of water, and the mixture was extracted four times with 80 ml of methylene chloride. The organic layer was dried over anhydrous sodium sulfate, and concentrated under reduced pressure. Crystallization of the residue from methylene chloride/carbon tetrachloride afforded 950 mg of α-methylsulfonyl(3-thienyl)acetic acid as pale yellow crystals having a melting point of 123 to 123.5° C.

Provenance & Evidence