Hydrogen Peroxide → HCID 20306499, compound

HRID 2164132Notes

Reaction equation

HRID 2164132 reaction equation
[CH3:1][S:2][CH:3]([C:7]1[CH:11]=[CH:10][S:9][CH:8]=1)[C:4]([OH:6])=[O:5].OO.[OH2:14].C[OH:16]>[O-][W]([O-])(=O)=O.[Na+].[Na+]>[CH3:1][S:2]([CH:3]([C:7]1[CH:11]=[CH:10][S:9][CH:8]=1)[C:4]([OH:6])=[O:5])(=[O:16])=[O:14]

Participants

6

Reactant 4

HCID 784Hydrogen PeroxideHCID 887MethanolHCID 962WaterHCID 20306501HCID 20306501, compound

Product 1

HCID 20306499HCID 20306499, compound

Reagents, catalysts & solvents 1

HCID 26052Sodium tungstateCatalyst

Procedure

α-Methylthio(3-thienyl)acetic acid (1.487 g) was dissolved in 20 ml of methanol, and 10 mg of sodium tungstate and 2.5 ml of a 30% aqueous solution of hydrogen peroxide were added. The mixture was stirred for 3 days. To the reaction mixture was added 50 ml of water, and the mixture was extracted four times with 80 ml of methylene chloride. The organic layer was dried over anhydrous sodium sulfate, and concentrated under reduced pressure. Crystallization of the residue from methylene chloride/carbon tetrachloride afforded 950 mg of α-methylsulfonyl(3-thienyl)acetic acid as pale yellow crystals having a melting point of 123 to 123.5° C.

Workup

  1. extractionthe mixture was extracted four times with 80 ml of methylene chloride
  2. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  3. concentrationconcentrated under reduced pressure
  4. customCrystallization of the residue from methylene chloride/carbon tetrachloride

Sources & evidence

ORD record
ord-73801b7b576d452194458f4096f28903
Source dataset
uspto-grants-1979_01
Patent number
US04137406

Reaction notes

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