反应详情

The damp 4-acetylbenzenesulfonyl chloride from 100 g. of sodium 4-acetylbenzenesulfonate is added to a stirred solution of 500 ml. of 50% aqueous 2-hydroxyethylamine. The mixture is stirred at room temperature for 16 hours, then acidified with hydrochloric acid and cooled to 0°-5° C. The precipitate of 4-acetyl-N-(2-hydroxyethyl)benzenesulfonamide is collected by filtration, washed with water and dried; m.p. 119°-121° C. after crystallization from water.

1. temperaturecooled to 0°-5° C
2. filtrationThe precipitate of 4-acetyl-N-(2-hydroxyethyl)benzenesulfonamide is collected by filtration
3. washwashed with water
4. customdried
5. customm.p. 119°-121° C. after crystallization from water