Dichloromethane → HCID 22750320, compound

HRID 2164161Notes

Reaction equation

HRID 2164161 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([NH:7][S:8]([C:11]2[CH:16]=[CH:15][C:14]([C:17]3[NH:18][C:19](=[O:26])[C:20](=[CH:24][CH:25]=3)[C:21](O)=O)=[CH:13][CH:12]=2)(=[O:10])=[O:9])[CH:2]=1.C(Cl)[Cl:28].C[Si]([Cl:34])(C)C.S(Cl)(Cl)=O>C(N(CC)CC)C>[ClH:28].[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([NH:7][S:8]([C:11]2[CH:16]=[CH:15][C:14]([C:17]3[NH:18][C:19](=[O:26])[C:20](=[CH:24][CH:25]=3)[CH2:21][Cl:34])=[CH:13][CH:12]=2)(=[O:10])=[O:9])[CH:2]=1

Participants

6

Reactant 4

HCID 6344DichloromethaneHCID 6397ChlorotrimethylsilaneHCID 24386Thionyl ChlorideHCID 22750275HCID 22750275, compound

Product 1

HCID 22750320HCID 22750320, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

From 4.0 g. of 6-[4-(3-pyridylaminosulfonyl)phenyl]-1,2-dihydro-2-oxonicotinic acid in 150 ml. of methylene chloride, 1.55 ml. of triethylamine, 1.4 ml. of trimethylsilyl chloride and 1.6 ml. of thionyl chloride, following the procedure of a) above, there is obtained 6-[4-(3-pyridylaminosulfonyl)phenyl]-1,2-dihydro-2-oxonicotinyl chloride hydrochloride.

Sources & evidence

ORD record
ord-2bfdede3ce2a477ba00ec6a99930289a
Source dataset
uspto-grants-1979_01
Patent number
US04137408

Reaction notes

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