Dichloromethane → HCID 22750312, compound

HRID 2164164Notes

Reaction equation

HRID 2164164 reaction equation
[N:1]1([S:7]([C:10]2[CH:15]=[CH:14][C:13]([C:16]3[NH:17][C:18](=[O:25])[C:19](=[CH:23][CH:24]=3)[C:20](O)=O)=[CH:12][CH:11]=2)(=[O:9])=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C(Cl)[Cl:27].C[Si](Cl)(C)C.S(Cl)(Cl)=O>C(N(CC)CC)C>[N:1]1([S:7]([C:10]2[CH:15]=[CH:14][C:13]([C:16]3[NH:17][C:18](=[O:25])[C:19](=[CH:23][CH:24]=3)[CH2:20][Cl:27])=[CH:12][CH:11]=2)(=[O:9])=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

6

Reactant 4

HCID 6344DichloromethaneHCID 6397ChlorotrimethylsilaneHCID 24386Thionyl ChlorideHCID 22750319HCID 22750319, compound

Product 1

HCID 22750312HCID 22750312, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

From 5.0 g. of 6-[4-(1-piperidinylsulfonyl)phenyl]-1,2-dihydro-2-oxonicotinic acid in 150 ml. of methylene chloride, 2.0 ml. of triethylamine, 1.75 ml. of trimethylsilyl chloride and 2.0 ml. of thionyl chloride, following the procedure of a) above, there is obtained 6-[4-(1-piperidinylsulfonyl)phenyl]-1,2-dihydro-2-oxonicotinyl chloride.

Sources & evidence

ORD record
ord-0b3abf5b4d7b42c88489ab7548f9562d
Source dataset
uspto-grants-1979_01
Patent number
US04137408

Reaction notes

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