Dichloromethane → HCID 22750299, compound

HRID 2164165Notes

Reaction equation

HRID 2164165 reaction equation
[CH2:1]([N:3]([CH2:23][CH3:24])[S:4]([C:7]1[CH:12]=[CH:11][C:10]([C:13]2[NH:14][C:15](=[O:22])[C:16](=[CH:20][CH:21]=2)[C:17](O)=O)=[CH:9][CH:8]=1)(=[O:6])=[O:5])[CH3:2].C(Cl)[Cl:26].C[Si](Cl)(C)C.S(Cl)(Cl)=O>C(N(CC)CC)C>[CH2:1]([N:3]([CH2:23][CH3:24])[S:4]([C:7]1[CH:12]=[CH:11][C:10]([C:13]2[NH:14][C:15](=[O:22])[C:16](=[CH:20][CH:21]=2)[CH2:17][Cl:26])=[CH:9][CH:8]=1)(=[O:6])=[O:5])[CH3:2]

Participants

6

Reactant 4

HCID 6344DichloromethaneHCID 6397ChlorotrimethylsilaneHCID 24386Thionyl ChlorideHCID 22750294HCID 22750294, compound

Product 1

HCID 22750299HCID 22750299, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

From 6.0 g. of 6-[4-(diethylaminosulfonyl)phenyl]-1,2-dihydro-2-oxonicotinic acid in 175 ml. of methylene chloride, 2.4 ml. of triethylamine, 2.2 ml. of trimethylsilyl chloride and 2.5 ml. of thionyl chloride, following the procedure of a) above, there is obtained 6-[4-(diethylaminosulfonyl)phenyl]-1,2-dihydro-2-oxonicotinyl chloride.

Sources & evidence

ORD record
ord-fe6dc00042a84ee4be61b15c4b750e52
Source dataset
uspto-grants-1979_01
Patent number
US04137408

Reaction notes

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