Pyridine → HCID 13455393, compound

HRID 2164196Notes

Reaction equation

HRID 2164196 reaction equation
[Cl:1][C:2]1[N:11]=[C:10](Cl)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[N:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[Cl-:1].[Cl:1][C:2]1[N:11]=[C:10]([N+:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

Participants

3

Reactant 2

HCID 1049PyridineHCID 2528862,4-Dichloroquinazoline

Product 1

HCID 13455393HCID 13455393, compound

Procedure

A 50-g portion of 2,4-dichloroquinazoline was added to 500 ml of pyridine at ambient temperature. The reaction was stirred overnight under a calcium sulfate drying tube, chilled and filtered. The solid was rinsed thoroughly with pyridine and dried in vacuo giving 65 g of solid 1-(2-chloroquinazoline-4-yl)pyridinium chloride (m.p. 105°-107° C.; mixture melting point with 2,4-dichloroquinazoline 80°-87° C.).

Workup

  1. temperaturechilled
  2. filtrationfiltered
  3. washThe solid was rinsed thoroughly with pyridine
  4. customdried in vacuo

Sources & evidence

ORD record
ord-ec24d9a92ce946939eee6dbf7e78f70d
Source dataset
uspto-grants-1985_03
Patent number
US04502880

Reaction notes

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