Sodium Bicarbonate → HCID 131714146, compound

Participants

Reaction Steps

A solution of 1.9 g of 2-[4-(4-chlorophenyl)-1-(4-fluorophenyl)-3-pyrazolyl]-1-hydroxyethane-1,1-diphosphonic acid in 5 ml of dimethylformamide is combined with a solution of 0.8 g of sodium bicarbonate in 10 ml of water and stirred for 2 hours at room temperature. Then the thus-precipitated product is vacuum-filtered, washed with a small amount of water, and dried at 110° C., yielding 1.6 g (76%) of 2-[4-(4-chlorophenyl)-1-(4-fluorophenyl)-3-pyrazolyl]-1-hydroxyethanediphosphonic acid disodium salt, mp above 300° C.

Provenance & Evidence